Candesartan cilexetil
Atacand, Candesartan Cilexetil (candesartan cilexetil) is a small molecule pharmaceutical. Candesartan cilexetil was first approved as Atacand on 1998-06-04. It is used to treat diabetic nephropathies, heart failure, hypertension, and left ventricular dysfunction in the USA.
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Trade Name
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Atacand, Candesartan cilexetil (discontinued: Candesartan cilexetil)
CombinationsAtacand, Candesartan cilexetil hydrochlorothiazide (discontinued: Candesartan cilexetil hydrochlorothiazide)
Drug Products
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Candesartan cilexetil
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| ATACAND | ANI Pharmaceuticals | N-020838 RX | 1998-06-04 | 4 products, RLD, RS |
Candesartan cilexetil
+
Hydrochlorothiazide
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| ATACAND HCT | ANI Pharmaceuticals | N-021093 RX | 2000-09-05 | 3 products, RLD |
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| atacand | New Drug Application | 2020-06-19 |
| atacand hct | New Drug Application | 2020-05-07 |
| candesartan | ANDA | 2022-12-28 |
| candesartan cilexetil | NDA authorized generic | 2024-10-14 |
| candesartan cilexetil and hydrochlorothiazide | ANDA | 2024-11-11 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
C: Cardiovascular system drugs
— C09: Agents acting on the renin-angiotensin system
— C09C: Angiotensin ii receptor blockers (arbs), plain
— C09CA: Angiotensin ii receptor blockers (arbs), plain
— C09CA06: Candesartan
— C09D: Angiotensin ii receptor blockers (arbs), combinations
— C09DA: Angiotensin ii receptor blockers (arbs) and diuretics
— C09DA06: Candesartan and diuretics
— C09DB: Angiotensin ii receptor blockers (arbs) and calcium channel blockers
— C09DB07: Candesartan and amlodipine
— C09DX: Angiotensin ii receptor blockers (arbs), other combinations
— C09DX06: Candesartan, amlodipine and hydrochlorothiazide
HCPCS
No data
Clinical
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Drug
General
| Drug common name | Candesartan cilexetil |
| INN | — |
| Description | Candesartan is a benzimidazolecarboxylic acid that is 1H-benzimidazole-7-carboxylic acid substituted by an ethoxy group at position 2 and a ({2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl}methyl) group at position 1. It is a angiotensin receptor antagonist used for the treatment of hypertension. It has a role as an antihypertensive agent, an angiotensin receptor antagonist, an environmental contaminant and a xenobiotic. It is a benzimidazolecarboxylic acid and a biphenylyltetrazole. It is a conjugate acid of a candesartan(2-). |
| Classification | Small molecule |
| Drug class | angiotensin II receptor antagonists |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 |
Identifiers
| PDB | — |
| CAS-ID | 139481-59-7 |
| RxCUI | 214354 |
| ChEMBL ID | CHEMBL1014 |
| ChEBI ID | 3348 |
| PubChem CID | 2541 |
| DrugBank | DB13919 |
| UNII ID | — |
Target
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Atacand – AstraZeneca
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Estimated US medical usage
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Safety
Black-box Warning
Black-box warning for: Atacand, Atacand hct, Candesartan, Candesartan cilexetil
Adverse Events
0 adverse events reported
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