Candesartan cilexetil
Atacand, Candesartan Cilexetil (candesartan cilexetil) is a small molecule pharmaceutical. Candesartan cilexetil was first approved as Atacand on 1998-06-04. It is used to treat diabetic nephropathies, heart failure, hypertension, and left ventricular dysfunction in the USA.
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Atacand, Candesartan cilexetil (discontinued: Candesartan cilexetil)
CombinationsAtacand, Candesartan cilexetil hydrochlorothiazide (discontinued: Candesartan cilexetil hydrochlorothiazide)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Candesartan cilexetil
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| ATACAND | ANI Pharmaceuticals | N-020838 RX | 1998-06-04 | 4 products, RLD, RS |
Candesartan cilexetil
+
Hydrochlorothiazide
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| ATACAND HCT | ANI Pharmaceuticals | N-021093 RX | 2000-09-05 | 3 products, RLD |
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| atacand | New Drug Application | 2020-06-19 |
| atacand hct | New Drug Application | 2020-05-07 |
| candesartan | ANDA | 2025-01-16 |
| candesartan cilexetil | NDA authorized generic | 2025-07-28 |
| candesartan cilexetil and hydrochlorothiazide | ANDA | 2024-11-11 |
Agency Specific
FDA
EMA
No data
Patent Expiration
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ATC Codes
C: Cardiovascular system drugs
— C09: Agents acting on the renin-angiotensin system
— C09C: Angiotensin ii receptor blockers (arbs), plain
— C09CA: Angiotensin ii receptor blockers (arbs), plain
— C09CA06: Candesartan
— C09D: Angiotensin ii receptor blockers (arbs), combinations
— C09DA: Angiotensin ii receptor blockers (arbs) and diuretics
— C09DA06: Candesartan and diuretics
— C09DB: Angiotensin ii receptor blockers (arbs) and calcium channel blockers
— C09DB07: Candesartan and amlodipine
— C09DX: Angiotensin ii receptor blockers (arbs), other combinations
— C09DX06: Candesartan, amlodipine and hydrochlorothiazide
HCPCS
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Clinical
Clinical Trials
201 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hypertension | D006973 | EFO_0000537 | I10 | 15 | 13 | 25 | 28 | 22 | 103 |
| Essential hypertension | D000075222 | — | I10 | 2 | 8 | 10 | 2 | 5 | 27 |
| Heart failure | D006333 | EFO_0003144 | I50 | — | 2 | 6 | 7 | 4 | 19 |
| Cardiovascular diseases | D002318 | EFO_0000319 | I98 | 1 | 1 | 4 | 4 | 4 | 14 |
| Healthy volunteers/patients | — | — | — | 11 | — | — | 1 | 1 | 13 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | 1 | 1 | — | 4 | 3 | 9 |
| Covid-19 | D000086382 | — | U07.1 | — | 2 | 4 | 2 | 1 | 8 |
| Obesity | D009765 | EFO_0001073 | E66.9 | 1 | 1 | — | 4 | 1 | 7 |
| Chronic renal insufficiency | D051436 | — | N18 | 1 | — | — | 3 | 2 | 6 |
| Stroke | D020521 | EFO_0000712 | I63.9 | — | — | 1 | 5 | — | 6 |
Show 32 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Migraine disorders | D008881 | EFO_0003821 | G43 | — | 2 | 1 | — | 1 | 3 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | 1 | 1 | — | 1 | 3 |
| Hypercholesterolemia | D006937 | — | — | — | — | 3 | — | — | 3 |
| Diabetic retinopathy | D003930 | EFO_0003770 | — | — | — | 3 | — | — | 3 |
| Cardiotoxicity | D066126 | EFO_1001482 | — | — | — | 1 | — | 1 | 2 |
| Liver cirrhosis | D008103 | EFO_0001422 | K74.0 | 1 | 1 | 1 | — | — | 2 |
| Fibrosis | D005355 | — | — | 1 | 1 | 1 | — | — | 2 |
| Aortic valve stenosis | D001024 | EFO_0000266 | — | — | — | 2 | — | — | 2 |
| Pathologic constriction | D003251 | — | — | — | — | 2 | — | — | 2 |
| Cardiomyopathies | D009202 | EFO_0000318 | I42 | — | 1 | 1 | — | — | 2 |
Show 19 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Headache | D006261 | — | R51 | — | 1 | — | — | 2 | 3 |
| Cognitive dysfunction | D060825 | — | G31.84 | — | 3 | — | — | — | 3 |
| Alzheimer disease | D000544 | EFO_0000249 | F03 | — | 2 | — | — | — | 2 |
| Pheochromocytoma | D010673 | — | — | — | 1 | — | — | — | 1 |
| Peripheral nervous system diseases | D010523 | — | G64 | — | 1 | — | — | — | 1 |
| Cocaine-related disorders | D019970 | — | F14 | — | 1 | — | — | — | 1 |
| Cardio-renal syndrome | D059347 | — | — | 1 | 1 | — | — | — | 1 |
| Liver diseases | D008107 | EFO_0001421 | K70-K77 | 1 | 1 | — | — | — | 1 |
| Alcoholic liver diseases | D008108 | EFO_0008573 | K70 | 1 | 1 | — | — | — | 1 |
| Hepatitis c | D006526 | — | B19.2 | — | 1 | — | — | — | 1 |
Show 8 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Bipolar disorder | D001714 | EFO_0000289 | F30.9 | 1 | — | — | — | — | 1 |
| Therapeutic equivalency | D013810 | — | — | 1 | — | — | — | — | 1 |
| Barrett esophagus | D001471 | EFO_0000280 | K22.7 | 1 | — | — | — | — | 1 |
| Hyperphosphatemia | D054559 | — | — | 1 | — | — | — | — | 1 |
| Substance-related disorders | D019966 | EFO_0003890 | F13 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Diabetic nephropathies | D003928 | EFO_0000401 | — | — | — | — | — | 2 | 2 |
| Myocardial ischemia | D017202 | EFO_1001375 | I20-I25 | — | — | — | — | 2 | 2 |
| Systolic heart failure | D054143 | EFO_1001207 | I50.20 | — | — | — | — | 1 | 1 |
| Frailty | D000073496 | — | R53.1 | — | — | — | — | 1 | 1 |
| Morbid obesity | D009767 | EFO_0001074 | — | — | — | — | — | 1 | 1 |
| Metabolic syndrome | D024821 | EFO_0000195 | E88.810 | — | — | — | — | 1 | 1 |
| Hypoglycemia | D007003 | — | E16.2 | — | — | — | — | 1 | 1 |
| Myocardial infarction | D009203 | EFO_0000612 | I21 | — | — | — | — | 1 | 1 |
| Acute coronary syndrome | D054058 | EFO_0005672 | — | — | — | — | — | 1 | 1 |
| Angina pectoris | D000787 | EFO_0003913 | I20 | — | — | — | — | 1 | 1 |
Show 9 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Candesartan cilexetil |
| INN | — |
| Description | Candesartan is a benzimidazolecarboxylic acid that is 1H-benzimidazole-7-carboxylic acid substituted by an ethoxy group at position 2 and a ({2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl}methyl) group at position 1. It is a angiotensin receptor antagonist used for the treatment of hypertension. It has a role as an antihypertensive agent, an angiotensin receptor antagonist, an environmental contaminant and a xenobiotic. It is a benzimidazolecarboxylic acid and a biphenylyltetrazole. It is a conjugate acid of a candesartan(2-). |
| Classification | Small molecule |
| Drug class | angiotensin II receptor antagonists |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 |
Identifiers
| PDB | — |
| CAS-ID | 139481-59-7 |
| RxCUI | 214354 |
| ChEMBL ID | CHEMBL1014 |
| ChEBI ID | 3348 |
| PubChem CID | 2541 |
| DrugBank | DB13919 |
| UNII ID | — |
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Atacand – AstraZeneca
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Safety
Black-box Warning
Black-box warning for: Atacand, Atacand hct, Candesartan, Candesartan cilexetil
Adverse Events
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26,326 adverse events reported
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